oral solid dosage form pharmaceuticals

Benecel™ hypromellose

Benecel™ hypromellose (hydroxypropyl-methylcellulose or HPMC)products are high purity, water-souble, nonionic cellulose ethers.  Benecel™ HPMC is a versatile excipient with a variety of applications.  HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled-release dosage forms.  The Benecel™ family of pharmaceutical products, including Benecel™ XR and XRF HPMC, custom grades of Benecel™ HPMC, and Benecel™ DC HPMC, provides a full portfolio to support the controlled release of a broad range of APIs and manufacturing processes.

Fill out the form to request a sample or to connect with one of our solvers to learn more or get help with your needs. 

directly compressible HPMC grades:

Directly compressible (DC) grades enable the production of controlled-release formulations with the convenience of the most widely used tablet-binding mechanism. These Benecel™ DC HPMC grades offer good powder flow, content uniformity, and compressibility, making them well suited for direct compression.

features and benefits:

  • improves product flow characteristics
  • reduces processing times
  • identical, stable dissolution profiles compared with “CR” grades
  • improves content uniformity
  • reduces production costs
  • retains tensile strength after double compaction (roller compaction) process

Benecel™ XR and XRF HPMC grades:

Benecel™ XR and XRF are high-viscosity grades of HPMC with optimized polymer structure and particle morphology for use in matrix controlled-release systems.

features and benefits:

  • optimized polymer structure and particle morphology
  • consistent particle size distribution and bulk density
  • enhanced compactibility at high tableting speeds vs standard grades
  • fine particle size grades available (XRF)

custom grades of HPMC for Controlled Release:

Achieving a desired drug-release profile has traditionally involved blends of different molecular weights of particular polymers. Blending, however, can increase release-profile variability. Custom grades of Benecel™ HPMC were developed to obviate the need for blending and offer a potential solution to the problem of dissolution variability.

features and benefits:

  • increase predictability and reproducibility of drug release profiles
  • decrease research and development time needed to optimize blend ratio
  • decrease manufacturing time- no need to blend and manage multiple raw materials
  • opportunity to develop custom excipients

contact us

Fill out the form to request a sample or to connect with one of our solvers to learn more about Benecel™ HPMC or get help with your needs. 

 

 

 

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