Ashland pharmaceuticals

Ashland webinar: klucel™ xtend HPC - new hydrophilic matrix polymer addresses the limitations of traditional hypromellose polymers


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date: Tuesday, October 11, 2022
time: 10:00 am EDT

Until now, there were limited options for managing the release profile of formulations, especially high dose controlled release formulations. Ashland’s step change hydroxypropyl cellulose, klucel™ xtend hpc, has been shown to match the release profile of hypromellose controlled-release formulations at half the polymer concentration.

The need for hot-melt extrusion (HME) polymers is expected to grow as the pharma industry moves to implement more continuous and sustainable processes. klucel™ xtend hpc is the only cellulosic excipient that provides a compendial extended-release polymer option for plasticizer-free HME. 

This new excipient offers versatility and can be applied in different technologies like wet-granulation, direct compression, and holt-melt extrusion across a broad range of APIs. 

key learning objectives 

you will learn about a new compendial cellulose ether excipient that: 

  • provides robust controlled release tablets at lower use levels than hpmc
  • reduces potential burst effects when delivering highly soluble drugs 
  • is processable via hot-melt extrusion 
  • and we will review case studies demonstrating performance with broad range of APIs and process technologies


speaker:

Kapish Karan, M.S. 
global OSD R&D leader, pharmaceuticals

Kapish’s work is focused on pharmaceutical oral solid dosage, leading long-term innovation and providing support for strategic customers. He has over 8 years of experience in film-coating applications, design of immediate- and modified-release coating products, unit operations associated with the preparation of oral solid dosage forms, and oral drug delivery. His recent interests have expanded into continuous processing as it relates to the manufacture of oral solid dosage forms. 

Kapish is a member of the American Association of Pharmaceutical Scientists. He has published and presented on granulation, coating technology and taste masking at various technical conferences. 

Visit with us about Klucel xtend™ hpc at: 

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